Reductions of aryl bromides in water at room temperature

James C Fennewald; Evan B Landstrom; Bruce H Lipshutz

doi:10.1016/j.tetlet.2015.02.066

Reductions of aryl bromides in water at room temperature

Tetrahedron Lett. 2015 Jun 3;56(23):3608-3611. doi: 10.1016/j.tetlet.2015.02.066.

Authors

James C Fennewald¹, Evan B Landstrom¹, Bruce H Lipshutz¹

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, Santa Barbara 93106 USA.

Abstract

Micellar nanoreactors derived from commercially available 'Nok' (SPGS-550-M), in the presence of Fu's catalyst and a mild hydride source (NaBH₄), are useful for facile debromination of functionalized aromatic derivatives. This mild and environemntally responsible process is utlized in water at room temperature, and the reaction mixtures can be smoothly recycled.

Keywords: Functional group tolerance; Green chemistry; Micellar catalysis; Mild debromination; Recycling.

Grants and funding

R01 GM086485/GM/NIGMS NIH HHS/United States