Increasing evidence points to a role of altered microbiota on inflammation, obesity, and other chronic conditions. This commentary addresses the connection between osteosarcopenic obesity syndrome, an impairment in bone, muscle, and adipose tissues that occurs concurrently, with the altered microbiota in elderly individuals, particularly those living in long-term care facilities. As elderly move to long-term care facilities, they experience changes in gut bacteria that might exasperate the underlying conditions such as osteosarcopenic obesity. These individuals have exponentially higher osteoporotic fracture rates and immobility impairments compared to independently living individuals. However, there is very limited research on this topic and more insight is needed on the impact of probiotic treatment and diet in older individuals, especially those with chronic conditions related to aging, such as osteosarcopenic obesity.