Abstract
Seven new benzoxazole derivatives, nocarbenzoxazoles A-G (1-7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-231, MDA-MB-435, HeLa, and PC3). Compounds 1-6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC₅₀ values of 3 and 1 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bacillus subtilis / drug effects
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Benzoxazoles / chemistry
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Benzoxazoles / isolation & purification*
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Benzoxazoles / pharmacology
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Candida albicans / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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HeLa Cells
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Hep G2 Cells
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium smegmatis / drug effects
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Nocardia / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Benzoxazoles
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nocarbenzoxazole G