Abstract
Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells. In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.
Copyright © 2015 Elsevier Inc. All rights reserved.
MeSH terms
-
Animals
-
Dengue / immunology*
-
Dengue / virology*
-
Dengue Virus / physiology*
-
Humans
-
Immunity, Innate*
-
Interferon Type I / immunology*
-
RNA, Viral / metabolism*
-
Transcription Factors / metabolism*
-
Ubiquitin-Protein Ligases / metabolism*
-
Virus Replication*
Substances
-
Interferon Type I
-
RNA, Viral
-
Transcription Factors
-
Ubiquitin-Protein Ligases