Dengue Non-coding RNA: TRIMmed for Transmission

Cell Host Microbe. 2015 Aug 12;18(2):133-4. doi: 10.1016/j.chom.2015.07.009.

Abstract

Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells. In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dengue / immunology*
  • Dengue / virology*
  • Dengue Virus / physiology*
  • Humans
  • Immunity, Innate*
  • Interferon Type I / immunology*
  • RNA, Viral / metabolism*
  • Transcription Factors / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*
  • Virus Replication*

Substances

  • Interferon Type I
  • RNA, Viral
  • Transcription Factors
  • Ubiquitin-Protein Ligases