Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

Molecules. 2015 Jul 30;20(8):13854-63. doi: 10.3390/molecules200813854.

Abstract

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.

Keywords: Amarylidaceae alkaloids; SAR; antiproliferative activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemical synthesis
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Humans
  • Liliaceae / chemistry
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic