[Experimental studies of the pathomechanism of portal encephalopathy. I. Changes in monoamine oxidase (MAO) activity in the cerebral cortex and cerebellum of rats after portacaval shunt]

Neuropatol Pol. 1989;27(2):199-207.
[Article in Polish]

Abstract

Rats with portacaval shunt (PCS) were used as a model of hepatic encephalopathy and compared to sham operated controls. Neurochemical studies in rats have demonstrated increased activity of MAO in brain cortex and cerebellum at 20, 40, and 60 days after surgery. The greatest increase of MAO activity was seen 60 days after PCS.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Cerebellum / enzymology*
  • Cerebral Cortex / enzymology*
  • Enzyme Activation
  • Hepatic Encephalopathy / enzymology
  • Hepatic Encephalopathy / etiology*
  • Male
  • Monoamine Oxidase / metabolism*
  • Portacaval Shunt, Surgical / adverse effects*
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Substances

  • Monoamine Oxidase