Sterically geared tris-thioureas; transmembrane chloride transporters with unusual activity and accessibility

Chem Commun (Camb). 2015 Sep 28;51(75):14235-8. doi: 10.1039/c5cc05737j. Epub 2015 Aug 11.

Abstract

Tris-N-arylthioureas derived in one step from 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene are remarkably effective anion carriers. With optimised aryl substituents their activities come close to the best currently known, suggesting that they might find use as readily available standards in anion transport research.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / metabolism
  • Chlorides / metabolism*
  • Crystallography, X-Ray
  • Ion Transport
  • Models, Molecular
  • Molecular Structure
  • Thiourea / chemical synthesis
  • Thiourea / chemistry*
  • Thiourea / metabolism*

Substances

  • Anions
  • Chlorides
  • Thiourea