Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI

Chem Commun (Camb). 2015 Sep 25;51(74):14119-22. doi: 10.1039/c5cc05348j.

Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Buffers
  • Carbon Isotopes
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Molecular Structure
  • Taurine / analogs & derivatives*
  • Taurine / chemistry

Substances

  • Buffers
  • Carbon Isotopes
  • Taurine
  • N-(2-acetamido)-2-aminoethanesulfonic acid