Comparison of Porcine Small Intestinal Submucosa versus Polypropylene in Open Inguinal Hernia Repair: A Systematic Review and Meta-Analysis

PLoS One. 2015 Aug 7;10(8):e0135073. doi: 10.1371/journal.pone.0135073. eCollection 2015.

Abstract

Background: A systematic review and meta-analysis was performed in randomized controlled trials (RCTs) to compare porcine small intestinal submucosa (SIS) with polypropylene in open inguinal hernia repair.

Method: Electronic databases MEDLINE, Embase, and the Cochrane Library were used to compare patient outcomes for the two groups via meta-analysis.

Result: A total of 3 randomized controlled trials encompassing 200 patients were included in the meta-analysis. There was no significant difference in recurrence (P = 0.16), hematomas (P = 0.06), postoperative pain within 30 days (P = 0.45), or postoperative pain after 1 year (P = 0.12) between the 2 groups. The incidence of discomfort was significantly lower (P = 0.0006) in the SIS group. However, the SIS group experienced a significantly higher incidence of seroma (P = 0.03).

Conclusions: Compared to polypropylene, using SIS in open inguinal hernia repair is associated with a lower incidence of discomfort and a higher incidence of seroma. However, well-designed larger RCT studies with a longer follow-up period are needed to confirm these findings.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Databases, Factual
  • Hematoma / etiology
  • Herniorrhaphy / instrumentation*
  • Herniorrhaphy / methods*
  • Humans
  • Intestine, Small / pathology*
  • Odds Ratio
  • Pain, Postoperative
  • Polypropylenes*
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Seroma / etiology
  • Surgical Mesh
  • Swine
  • Treatment Outcome

Substances

  • Polypropylenes

Grants and funding

This work was supported by National Natural Science Foundation of China (81270444).