Hemolytic Disorders Causing Severe Neonatal Hyperbilirubinemia

Robert D Christensen; Hassan M Yaish

doi:10.1016/j.clp.2015.04.007

Hemolytic Disorders Causing Severe Neonatal Hyperbilirubinemia

Clin Perinatol. 2015 Sep;42(3):515-27. doi: 10.1016/j.clp.2015.04.007. Epub 2015 May 26.

Authors

Robert D Christensen¹, Hassan M Yaish²

Affiliations

¹ Women and Newborn's Program, Division of Neonatology, Department of Pediatrics, Intermountain Healthcare, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT 84108, USA; Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: Robert.christensen@hsc.utah.edu.
² Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.

PMID: 26250914
DOI: 10.1016/j.clp.2015.04.007

Abstract

A shortened erythrocyte life span, because of hemolytic disorders, is a common cause of extreme neonatal hyperbilirubinemia. Clinical and laboratory examinations can frequently identify the underlying cause of extreme neonatal hyperbilirubinemia. In this article, several tests, techniques, and approaches have been reviewed, including red blood cell morphology assessment, end-tidal carbon monoxide quantification, eosin-5-maleimide flow cytometry, as well as next-generation DNA sequencing using neonatal jaundice panels.

Keywords: Anemia; BIND; Bilirubin; End-tidal carbon monoxide; Hemoglobin; Jaundice; Kernicterus; Next-generation DNA sequencing.

Publication types

Review

MeSH terms

Hematologic Diseases / complications*
Humans
Hyperbilirubinemia, Neonatal / diagnosis
Hyperbilirubinemia, Neonatal / etiology*
Infant, Newborn
Risk Factors
Severity of Illness Index