DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

Affiliations

• ¹ Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
• ² Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
• ³ Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
• ⁴ Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.
• ⁵ Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Cambridge Blood and Stem Cell Bank, University of Cambridge, UK.
• ⁶ Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK arg1000@cam.ac.uk.