Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Anne-Marie Haaparanta; Peter Uppstu; Markus Hannula; Ville Ellä; Ari Rosling; Minna Kellomäki

doi:10.1016/j.msec.2015.07.013

Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Mater Sci Eng C Mater Biol Appl. 2015 Nov 1:56:457-66. doi: 10.1016/j.msec.2015.07.013. Epub 2015 Jul 15.

Authors

Anne-Marie Haaparanta¹, Peter Uppstu², Markus Hannula³, Ville Ellä⁴, Ari Rosling⁵, Minna Kellomäki⁶

Affiliations

¹ Department of Electronics and Communications Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720 Tampere, Finland; BioMediTech, Institute of Biosciences and Medical Technology, Biokatu 10, 33520 Tampere, Finland. Electronic address: anne-marie.haaparanta@tut.fi.
² Laboratory of Polymer Technology, Centre of Excellence in Functional Materials at Biological Interfaces, Åbo Akademi University, Biskopsgatan 8, 20500 Åbo, Finland. Electronic address: peter.uppstu@abo.fi.
³ Department of Electronics and Communications Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720 Tampere, Finland; BioMediTech, Institute of Biosciences and Medical Technology, Biokatu 10, 33520 Tampere, Finland. Electronic address: markus.hannula@tut.fi.
⁴ Department of Electronics and Communications Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720 Tampere, Finland; BioMediTech, Institute of Biosciences and Medical Technology, Biokatu 10, 33520 Tampere, Finland. Electronic address: ville.ella@arcticbiomaterials.com.
⁵ Laboratory of Polymer Technology, Centre of Excellence in Functional Materials at Biological Interfaces, Åbo Akademi University, Biskopsgatan 8, 20500 Åbo, Finland. Electronic address: ari.rosling@abo.fi.
⁶ Department of Electronics and Communications Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720 Tampere, Finland; BioMediTech, Institute of Biosciences and Medical Technology, Biokatu 10, 33520 Tampere, Finland. Electronic address: minna.kellomaki@tut.fi.

PMID: 26249615
DOI: 10.1016/j.msec.2015.07.013

Abstract

Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.

Keywords: Bioactive glass; Bone; Composite; Freeze-drying; Poly(d,l-lactide-co-glycolide); Tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Regeneration
Glass / chemistry*
Polyglactin 910 / chemistry*
Porosity
Tissue Engineering
Tissue Scaffolds / chemistry*

Substances

Polyglactin 910