Giant polarization rotation in a ZnO single crystal was experimentally demonstrated based on a novel phenomenon occurring at the nanometric scale. The ZnO crystal was doped with N(+) and N(2+) ions serving as p-type dopants. By applying an in-plane current using a unique arrangement of electrodes on the device, current-induced polarization rotation of the incident light was observed. From the results of experimental demonstrations and discussions, it was verified that this novel behavior originates from a specific distribution of dopants and the corresponding light-matter interactions in a nanometric space, which are allowed by the existence of such a dopant distribution.