Fluorescently labelled glycans and their applications

Glycoconj J. 2015 Nov;32(8):559-74. doi: 10.1007/s10719-015-9611-9. Epub 2015 Aug 4.

Abstract

This review summarises the literature on the synthesis and applications of fluorescently labelled carbohydrates. Due to the sensitivity of fluorescent detection, this approach provides a useful tool to study processes involving glycans. A few general categories of labelling are presented, in situ labelling of carbohydrates with fluorophores, fluorescently labelled glycolipids, fluorogenic glycans, pre-formed fluorescent glycans for intracellular applications, glycan-decorated fluorescent polymers, fluorescent glyconanoparticles, and other functional fluorescent glycans.

Keywords: Carbohydrate detection; Fluorescent labelling; Fluorescent polymer; Fluorescently labelled glycolipid; Fluorogenic glycoside; Glycan; Glyconanoparticle; Lectin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / metabolism
  • Boron Compounds / chemistry
  • Boronic Acids / chemistry
  • Carbohydrates / chemistry*
  • Fluorescent Dyes / chemistry*
  • Glycolipids / chemistry
  • Glycosides / chemistry
  • Humans
  • Ions
  • Lectins / chemistry
  • Mice
  • Nanoparticles / chemistry*
  • Polymers / chemistry
  • Polysaccharides / chemistry*

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Boronic Acids
  • Carbohydrates
  • Fluorescent Dyes
  • Glycolipids
  • Glycosides
  • Ions
  • Lectins
  • Polymers
  • Polysaccharides