A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius

Nat Prod Res. 2016;30(5):565-9. doi: 10.1080/14786419.2015.1033624. Epub 2015 Jul 31.

Abstract

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its (1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.

Keywords: Abelmoschus sagittifolius; cytotoxicity; sesquiterpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abelmoschus / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Plant Roots / chemistry
  • Polycyclic Sesquiterpenes
  • Quinones / chemistry*
  • Quinones / isolation & purification
  • Quinones / pharmacology
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents, Phytogenic
  • Polycyclic Sesquiterpenes
  • Quinones
  • Sesquiterpenes
  • acyl hibiscone B