Crinone Gel for Luteal Phase Support in Frozen-Thawed Embryo Transfer Cycles: A Prospective Randomized Clinical Trial in the Chinese Population

PLoS One. 2015 Jul 29;10(7):e0133027. doi: 10.1371/journal.pone.0133027. eCollection 2015.

Abstract

To compare Crinone vaginal progesterone gel with intramuscularly injected progesterone for luteal phase support in progesterone-supplemented frozen-thawed embryo transfer (FET) cycles, a randomized prospective study of patients qualified for FET was conducted between September 2010 and January 2013 at a hospital in Shanghai, China. From the day of transformation into secretory phase endometrium (day 0), Crinone vaginal gel (90 mg/d) was administered to patients in the Gel Group, while progesterone (40 mg/d) was injected intramuscularly in patients in the Inj Group (n = 750 per group). All patients received oral dydrogesterone (20 mg/d) and estradiol valerate (4–8 mg/d). Day 3 embryos with the highest pre-frozen scores were transferred to patients in the two groups and the clinical outcomes compared. This study comprised 1,500 cycles (750 in each group). Twenty-nine cycles in the Gel Group and 24 in the Inj Group were withdrawn. There were no significant differences between groups in age, endometrial thickness, endometrial preparation time or number of embryos transferred. No significant differences were observed between the Gel Group and Inj Group in the rates of live birth (32.6% vs. 31.7%, P = 0.71), clinical pregnancy (40.1% vs. 40.6%, P = 0.831), implantation (25.8% vs. 25.3%, P = 0.772), abortion (16.3% vs. 18.3%, P = 0.514) or ectopic pregnancy (2.8% vs. 4.4%, P = 0.288). Multivariate logistic regression analysis revealed that the odds ratios (95% confidence intervals) for the rates of live birth, clinical pregnancy, abortion and ectopic pregnancy (Gel Group relative to Inj Group) were 1.036 (0.829–1.295), 0.971 (0.785–1.200), 0.919 (0.595–1.420) and 0.649 (0.261–1.614), respectively. Our study revealed that using Crinone vaginal gel in FET cycles achieved similar pregnancy outcomes to intramuscular progesterone, indicating that vaginal gel is a viable alternative to intramuscular injection.

Trial registration: Chinese Clinical Trial Registry ChiCTR-TRC-14004565.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Embryo Transfer*
  • Female
  • Fertilization in Vitro
  • Follow-Up Studies
  • Humans
  • Injections, Intramuscular
  • Luteal Phase / drug effects*
  • Ovulation Induction
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Progesterone / administration & dosage
  • Progesterone / analogs & derivatives*
  • Progestins / administration & dosage
  • Prospective Studies
  • Vaginal Creams, Foams, and Jellies / administration & dosage*

Substances

  • Crinone
  • Progestins
  • Vaginal Creams, Foams, and Jellies
  • Progesterone

Associated data

  • ChiCTR/CHICTR-TRC-14004565

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81370762), the Key Program for Basic Research of the Science and Technology Commission of Shanghai Municipality, China (Grant No. 12JC1405800), The National Basic Research Program (973 Program) (Grant No. 2014CB943300), the Research Special Fund of National Health and Family Planning Commission, China (Grant No. 201402004), and Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics (Grant No. 12DZ2260600). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.