Polymeric biomaterials for the delivery of platinum-based anticancer drugs

Biomater Sci. 2015 Jul;3(7):1002-17. doi: 10.1039/c5bm00039d. Epub 2015 Apr 20.

Abstract

Since cisplatin, cis-diamminedichloroplatinum(ii), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Biocompatible Materials / therapeutic use
  • Cisplatin / chemistry
  • Cisplatin / therapeutic use*
  • Drug Delivery Systems
  • Humans
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy
  • Platinum / chemistry
  • Platinum / therapeutic use*
  • Polymers / chemistry*

Substances

  • Antineoplastic Agents
  • Biocompatible Materials
  • Polymers
  • Platinum
  • Cisplatin