Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

Biosci Biotechnol Biochem. 2015;79(12):2018-21. doi: 10.1080/09168451.2015.1065170. Epub 2015 Jul 27.

Abstract

Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.

Keywords: UV-B radiation; ginsenoside Ro; glutathione; oxidative stress; reactive oxygen species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / pharmacology
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Fibroblasts / cytology
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism
  • Fibroblasts / radiation effects*
  • Ginsenosides / pharmacology*
  • Humans
  • Matrix Metalloproteinase 2 / metabolism
  • Oxidative Stress / drug effects*
  • Oxidative Stress / radiation effects*
  • Reactive Oxygen Species / metabolism
  • Skin / cytology*
  • Ultraviolet Rays / adverse effects*

Substances

  • Antioxidants
  • Ginsenosides
  • Reactive Oxygen Species
  • ginsenoside Ro
  • Matrix Metalloproteinase 2