Abstract
Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.
Keywords:
UV-B radiation; ginsenoside Ro; glutathione; oxidative stress; reactive oxygen species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / pharmacology
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Fibroblasts / cytology
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Fibroblasts / drug effects*
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Fibroblasts / metabolism
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Fibroblasts / radiation effects*
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Ginsenosides / pharmacology*
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Humans
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Matrix Metalloproteinase 2 / metabolism
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Oxidative Stress / drug effects*
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Oxidative Stress / radiation effects*
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Reactive Oxygen Species / metabolism
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Skin / cytology*
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Ultraviolet Rays / adverse effects*
Substances
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Antioxidants
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Ginsenosides
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Reactive Oxygen Species
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ginsenoside Ro
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Matrix Metalloproteinase 2