Abstract
Moderate exogenous hyperhomocysteinemia is associated with an increase in lymphocyte count (mainly at the expense of cytotoxic T cells), a 2-fold drop of the immunoregulatory index, and increase in TNF-α, IFN-γ, and IL-17α concentrations in the serum and in mononuclear cells. Homocysteine concentration in the mononuclears remains unchanged.
MeSH terms
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Animals
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Cytokines / metabolism*
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Hyperhomocysteinemia / immunology*
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Hyperhomocysteinemia / metabolism*
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Interferon-gamma / metabolism
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Interleukin-17 / metabolism
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Lymphocyte Subsets / metabolism*
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Male
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Rats
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Cytokines
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Interleukin-17
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Tumor Necrosis Factor-alpha
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Interferon-gamma