Two new lignans from twigs of Aglaia odorata

J Asian Nat Prod Res. 2016;18(2):147-52. doi: 10.1080/10286020.2015.1057575. Epub 2015 Jul 24.

Abstract

HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.

Keywords: 3′-methoxy-N-demethylrocaglamide; 4′-O-demethyl-deacetylaglaxiflorin A; Aglaia odorata; Meliaceae; cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aglaia / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • HeLa Cells
  • Humans
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Stems / chemistry
  • Stomach Neoplasms / drug therapy

Substances

  • 3'-methoxy-N-demethylrocaglamide
  • 4'-O-demethyl-deacetylaglaxiflorin A
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Lignans