Efficient Self-Assembly of Di-, Tri-, Tetra-, and Hexavalent Hosts with Predefined Geometries for the Investigation of Multivalency

Igor Linder; Stefan Leisering; Rakesh Puttreddy; Nadine Rades; Kari Rissanen; Christoph A Schalley

doi:10.1002/chem.201502056

Efficient Self-Assembly of Di-, Tri-, Tetra-, and Hexavalent Hosts with Predefined Geometries for the Investigation of Multivalency

Chemistry. 2015 Sep 7;21(37):13035-44. doi: 10.1002/chem.201502056. Epub 2015 Jul 21.

Authors

Igor Linder¹, Stefan Leisering¹, Rakesh Puttreddy², Nadine Rades¹, Kari Rissanen², Christoph A Schalley³

Affiliations

¹ Institut für Chemie und Biochemie der Freien Universität Berlin, Takustrasse 3, 14195 Berlin (Germany).
² University of Jyvaskyla, Department of Chemistry, Nanoscience Center, P.O. Box. 35, 40014 University of Jyvaskyla (Finland).
³ Institut für Chemie und Biochemie der Freien Universität Berlin, Takustrasse 3, 14195 Berlin (Germany). c.schalley@fu-berlin.de.

PMID: 26206383
DOI: 10.1002/chem.201502056

Abstract

Coordination-driven self-assembly of differently shaped di- to hexavalent crown-ether host molecules is described. A series of [21]crown-7- and [24]crown-8-substituted bipyridine and terpyridine ligands was synthetized in a "toolbox" approach. Subsequent coordination to 3d transition metal and ruthenium(II) ions provides an easy and fast access to host assemblies with variable valency and pre-defined orientations of the crown-ether moieties. Preliminary isothermal calorimetry (ITC) titrations provided promising results, which indicated the host complexes under study to be suitable for the future investigation of multivalent and cooperative binding. The hosts described herein will also be suitable for the construction of various multiply threaded mechanically interlocked molecules.

Keywords: coordination chemistry; crown ethers; multivalency; pseudorotaxanes; supramolecular chemistry.