Promiscuity of autoimmune responses to MBP after stroke

J Neuroimmunol. 2015 Aug 15:285:101-5. doi: 10.1016/j.jneuroim.2015.05.024. Epub 2015 May 28.

Abstract

In this study we examined Th1 and Th17 immune responses to rat myelin basic protein (MBP), bovine MBP, human MBP, MBP 68-86, MBP 63-81 and ovalbumin in Lewis rats to determine which MBP antigen is recognized following ischemic brain injury. Responses were compared to animals immunized to rat MBP. Data show that immune responses following immunization with rat MBP are promiscuous with cross reaction to MBP from other species. After stroke, few animals develop Th1 or Th17 responses to MBP, but when those responses occur, especially Th1 responses to rat MBP in the brain, they are predictive of worse stroke outcome.

Keywords: Immune response; MBP; Stroke; Th1; Th17.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Autoimmunity / drug effects
  • Autoimmunity / immunology*
  • Brain / drug effects
  • Brain / immunology
  • Cattle
  • Humans
  • Myelin Basic Protein / pharmacology*
  • Myelin Basic Protein / therapeutic use*
  • Rats
  • Rats, Inbred Lew
  • Stroke / drug therapy*
  • Stroke / immunology*
  • Th1 Cells / drug effects
  • Th1 Cells / immunology
  • Th17 Cells / drug effects
  • Th17 Cells / immunology

Substances

  • Mbp protein, rat
  • Myelin Basic Protein