Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis

J Neuroimmunol. 2015 Aug 15:285:16-21. doi: 10.1016/j.jneuroim.2015.05.010. Epub 2015 May 13.

Abstract

In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.

Keywords: Dimethylfumarate; Nrf2; OSE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / immunology
  • Demyelinating Diseases / pathology
  • Disease Models, Animal*
  • Dose-Response Relationship, Drug
  • Encephalomyelitis, Autoimmune, Experimental / drug therapy*
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / pathology*
  • Esters
  • Fumarates / administration & dosage*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology

Substances

  • Esters
  • Fumarates