Effect of the order of TBI and cyclophosphamide administration on the outcome of allogeneic hematopoietic stem cell transplantation

K Motohashi; S Fujisawa; M Onizuka; S Kako; E Sakaida; K Shono; R Tatara; N Doki; T Mori; T Sakura; N Aotsuka; E Fuji; N Tomita; N Kawai; T Saitoh; K Usuki; J Taguchi; R Watanabe; S Kobayashi; S Yano; H Kanamori; S Takahashi; S Okamoto

doi:10.1038/bmt.2015.142

Effect of the order of TBI and cyclophosphamide administration on the outcome of allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplant. 2015 Nov;50(11):1476-9. doi: 10.1038/bmt.2015.142. Epub 2015 Jul 20.

Authors

K Motohashi¹, S Fujisawa¹, M Onizuka², S Kako³, E Sakaida⁴, K Shono⁵, R Tatara⁶, N Doki⁷, T Mori⁸, T Sakura⁹, N Aotsuka¹⁰, E Fuji¹¹, N Tomita¹², N Kawai¹³, T Saitoh¹⁴, K Usuki¹⁵, J Taguchi¹⁶, R Watanabe¹⁷, S Kobayashi¹⁸, S Yano¹⁹, H Kanamori¹¹, S Takahashi²⁰, S Okamoto⁸

Affiliations

¹ Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan.
² Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
³ Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan.
⁴ Division of Hematology, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan.
⁵ Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
⁶ Division of Hematology, Jichi Medical University, Shimotsuke, Japan.
⁷ Division of Hematology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.
⁸ Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
⁹ Leukemia Research Center, Gunmaken Saiseikai Maebashi Hospital, Maebashi, Japan.
¹⁰ Department of Hematology and Oncology, Japanese Red Cross Narita Hospital, Narita, Japan.
¹¹ Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
¹² Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
¹³ Department of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan.
¹⁴ Department of Hematology, Gunma University Hospital, Maebashi, Japan.
¹⁵ Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan.
¹⁶ Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan.
¹⁷ Department of Hematology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
¹⁸ Department of Hematology, Nihon University Itabashi Hospital, Tokyo, Japan.
¹⁹ Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
²⁰ Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

PMID: 26191948
DOI: 10.1038/bmt.2015.142

No abstract available

Publication types

Comparative Study
Letter

MeSH terms

Allografts
Animals
Child
Cyclophosphamide / administration & dosage*
Cyclophosphamide / adverse effects
Cyclophosphamide / therapeutic use
Cytokines / metabolism
Disease Models, Animal
Female
Follow-Up Studies
Graft vs Host Disease / epidemiology
Graft vs Host Disease / etiology*
Graft vs Host Disease / prevention & control
Hematologic Neoplasms / therapy
Hematopoietic Stem Cell Transplantation / adverse effects
Hematopoietic Stem Cell Transplantation / methods*
Humans
Lymphocyte Transfusion / adverse effects
Male
Mice
Myelodysplastic Syndromes / therapy
Recurrence
Retrospective Studies
Time Factors
Transplantation Conditioning / adverse effects
Transplantation Conditioning / methods*
Treatment Outcome
Whole-Body Irradiation / adverse effects
Whole-Body Irradiation / methods*

Substances

Cytokines
Cyclophosphamide