Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody

Gene Ther. 2015 Dec;22(12):960-7. doi: 10.1038/gt.2015.71. Epub 2015 Jul 16.

Abstract

The ganglioside GM3(Neu5Gc) has gained increasing attention as therapeutic target because of its selective expression in various human tumours, such as melanoma, breast and lung cancer. 14F7 is a mouse IgG1 with specific reactivity to GM3(Neu5Gc)-positive tumours. The therapeutic activity of 14F7 has also been demonstrated in vivo, through its repetitive passive administration in tumour-bearing animals. In this work we used an alternative strategy to deliver recombinant 14F7 in vivo and analysed the therapeutic efficacy of this approach. We engineered a recombinant adeno-associated vector to direct the expression of secretable recombinant 14F7 in BALB/c animals. A single administration of the rAAV induced efficient production and secretion of the antibody in the bloodstream, with an expression level reaching plateau at ∼3 weeks after injection and persisting for almost a year. Strikingly, upon challenge with GM3(Neu5Gc)-positive X63-AG8.653 myeloma cells, tumour development was significantly delayed in animals treated with rAAV-14F7 with respect to animals treated with a control rAAV codifying for an irrelevant antibody. Finally, no significant differences in survival proportion were detected in animals injected with rAAV-14F7 or treated by standard administration of repetitive doses of purified monoclonal antibody 14F7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal / biosynthesis*
  • Antibodies, Monoclonal / immunology*
  • Dependovirus / genetics
  • Dependovirus / metabolism
  • G(M3) Ganglioside / immunology*
  • HEK293 Cells
  • Humans
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin G / immunology
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / therapy
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism

Substances

  • Antibodies, Monoclonal
  • G(M3) Ganglioside
  • Immunoglobulin G
  • Recombinant Proteins