Animal models of respiratory syncytial virus infection and disease

Randy E Sacco; Russell K Durbin; Joan E Durbin

doi:10.1016/j.coviro.2015.06.003

Animal models of respiratory syncytial virus infection and disease

Curr Opin Virol. 2015 Aug:13:117-22. doi: 10.1016/j.coviro.2015.06.003. Epub 2015 Jul 11.

Authors

Randy E Sacco¹, Russell K Durbin², Joan E Durbin³

Affiliations

¹ Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, United States.
² Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States.
³ Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States; Department of Pathology, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, United States. Electronic address: durbinje@njms.rutgers.edu.

Abstract

The study of human respiratory syncytial virus pathogenesis and immunity has been hampered by its exquisite host specificity, and the difficulties encountered in adapting this virus to a murine host. The reasons for this obstacle are not well understood, but appear to reflect, at least in part, the inability of the virus to block the interferon response in any but the human host. This review addresses some of the issues encountered in mouse models of respiratory syncytial virus infection, and describes the advantages and disadvantages of alternative model systems.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Respiratory Syncytial Virus Infections / virology*
Respiratory Syncytial Virus, Human / genetics
Respiratory Syncytial Virus, Human / physiology*

Abstract

Publication types

MeSH terms

Grants and funding