Two new Lycopodium alkaloids from Phlegmariurus phlegmaria (L.) Holub

Zhichong Wang; Jichun Wu; Ningdong Zhao; Yiyu Yang; Yegao Chen

doi:10.1080/14786419.2015.1046131

Two new Lycopodium alkaloids from Phlegmariurus phlegmaria (L.) Holub

Nat Prod Res. 2016;30(2):241-5. doi: 10.1080/14786419.2015.1046131. Epub 2015 Jul 13.

Authors

Zhichong Wang¹, Jichun Wu², Ningdong Zhao³, Yiyu Yang¹, Yegao Chen¹

Affiliations

¹ a Department of Medicinal Chemistry, School of Chemistry and Chemical Engineering, Yunnan Normal University , Chenggong New District, Kunming 650500 , China.
² b Department of Natural Medicinal Chemistry, College of Pharmacy, Yanbian University , Yanji 133002 , China.
³ c Department of Chemistry and Engineering , Wenshan College , Wenshan 663000 , China.

PMID: 26166258
DOI: 10.1080/14786419.2015.1046131

Abstract

Two new Lycopodium alkaloids, 4β-hydroxynankakurine B (1) and Δ(13,N),N(α)-methylphlegmarine-N(β)-oxide (2), together with three known analogues, lycoposerramine E (3), nankakurine B (4) and lobscurinol (5), were isolated from Phlegmariurus phlegmaria. Their structures were established by mass spectrometry and 1D and 2D NMR techniques.

Keywords: Huperziaceae; Lycopodium alkaloids; Phlegmariurus phlegmaria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Heterocyclic Compounds, Bridged-Ring / chemistry
Heterocyclic Compounds, Bridged-Ring / isolation & purification
Huperzia / chemistry*
Lycopodium / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Spectrometry, Mass, Electrospray Ionization

Substances

Alkaloids
Heterocyclic Compounds, Bridged-Ring
nankakurine B