An Organic Field-effect Transistor with an Extended-gate Electrode Capable of Detecting Human Immunoglobulin A

Anal Sci. 2015;31(7):725-8. doi: 10.2116/analsci.31.725.

Abstract

We herein report on the development of an extended-gate type organic field-effect transistor (OFET)-based immunosensor for the detection of human immunoglobulin A (IgA). The titration results of IgA exhibited shifts in the transfer characteristics of the OFET sensor device with increasing IgA concentration. A linear detection range from 0 to 10 μg/mL was realized with a detection limit of 2.1 μg/mL, indicating that the OFET-based immunosensor can be potentially applied to the monitoring of infectious diseases and psychological stress in daily life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Electrochemistry
  • Electrodes
  • Humans
  • Immunoassay
  • Immunoglobulin A / analysis*
  • Immunoglobulin A / chemistry
  • Limit of Detection
  • Organic Chemicals / chemistry*
  • Transistors, Electronic*
  • Water / chemistry

Substances

  • Immunoglobulin A
  • Organic Chemicals
  • Water