Strain Variation and Disease Severity in Congenital Cytomegalovirus Infection: In Search of a Viral Marker

Abstract

The wide spectrum of congenital cytomegalovirus (CMV) disease and known differences in the biology and in vitro growth of CMV strains continue to drive studies in search for specific viral genetic determinants that may predict severity of congenital CMV disease. Several CMV genes have been studied in detail in congenitally infected children, but the complexity of the viral genome and differences in the definition of symptomatic disease versus asymptomatic CMV infection continue to raise questions related to what constitutes a pathogenic CMV strain.

Keywords: Congenital infection; Cytomegalovirus; Genotypes; Immune evasion genes; Multiple strains; Next-generation sequencing; Population-based sequencing; Strains.