Effects of interleukin-17A on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching

R S Ovchinnikov; V M Mitrokhin; M I Mladenov

doi:10.1016/j.cyto.2015.06.016

Effects of interleukin-17A on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching

Cytokine. 2015 Dec;76(2):561-565. doi: 10.1016/j.cyto.2015.06.016. Epub 2015 Jul 4.

Authors

R S Ovchinnikov¹, V M Mitrokhin², M I Mladenov³

Affiliations

¹ Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies of the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
² Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
³ Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, Macedonia. Electronic address: m.mitko@gmail.com.

PMID: 26153393
DOI: 10.1016/j.cyto.2015.06.016

Abstract

Using microelectrode technique we studied the effects of interleukin-17A on the activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. Perfusion with interleukin-17A for 35 min without stretch, led to an increase in APD25, APD50 and APD90. The effect on the frequency and force of the contraction was absent. Stretching during interleukin-17A perfusion led to an increase only at the level of APD90. In the same condition, the repetition frequency of the action potentials did not change as well. Close observation of the cytokine induced mechanisms, confirmed that IL-17A act on different levels and induce different signaling pathways involved in the regulation of cardiac function.

Keywords: Action potential; Atrium; Heart; Interleukin-17A; Stretch.

MeSH terms

Action Potentials
Animals
Heart / physiology*
Interleukin-17 / physiology*
Male
Rats
Rats, Wistar

Substances

Il17a protein, rat
Interleukin-17