Glucose monomycolates based on single synthetic mycolic acids

Mohaned M Sahb; Juma'a R Al Dulayymi; Mark S Baird

doi:10.1016/j.chemphyslip.2015.06.005

Glucose monomycolates based on single synthetic mycolic acids

Chem Phys Lipids. 2015 Sep:190:9-14. doi: 10.1016/j.chemphyslip.2015.06.005. Epub 2015 Jul 2.

Authors

Mohaned M Sahb¹, Juma'a R Al Dulayymi¹, Mark S Baird²

Affiliations

¹ School of Chemistry, Bangor University, Bangor, Gwynedd LL57 2UW, UK.
² School of Chemistry, Bangor University, Bangor, Gwynedd LL57 2UW, UK. Electronic address: chs028@bangor.ac.uk.

PMID: 26143625
DOI: 10.1016/j.chemphyslip.2015.06.005

Abstract

The preparation of 6-O-mycolylglucoses (GMMs) from single synthetic mycolic acids matching the overall structure of some of the major natural glucose monomycolates of Mycobacterium tuberculosis and other mycobacteria is reported.

Keywords: GMM; Glucose monomycolate; Keto-mycolic acid; Methoxy-mycolic acid; Synthesis; α-Mycolic acid.

MeSH terms

Glycolipids / chemical synthesis*
Glycolipids / chemistry
Molecular Conformation
Mycobacterium / chemistry*
Mycolic Acids / chemistry*

Substances

Glycolipids
Mycolic Acids
glucose mycolate