Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections

Jacqueline A Guidry; Christopher Downing; Stephen K Tyring

doi:10.1016/j.det.2015.03.019

Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections

Dermatol Clin. 2015 Jul;33(3):595-607. doi: 10.1016/j.det.2015.03.019.

Authors

Jacqueline A Guidry¹, Christopher Downing², Stephen K Tyring³

Affiliations

¹ Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA.
² Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA. Electronic address: cdowning@ccstexas.com.
³ Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA; Department of Dermatology, University of Texas Health Science Center, 6655 Travis, Suite 600, Houston, TX 77003, USA.

PMID: 26143434
DOI: 10.1016/j.det.2015.03.019

Abstract

Granulomatous diseases are caused by multiple infectious and noninfectious causes. Deep fungal infections can present in the skin or extracutaneously, most commonly with lung manifestations. An Azole or amphotericin B is the universal treatment. Blastomycosis-like pyoderma is a clinically similar condition, which is caused by a combination of hypersensitivity and immunosuppression. Successful treatment has been reported with antibiotics and, more recently, the vitamin A analog, acitretin. Granuloma inguinale and lymphogranuloma venereum cause ulcerative genital lesions with a granulomatous appearance on histology. The Centers for Disease Control and Prevention recommens treatment of these genital infections with doxycycline.

Keywords: Blastomycosis-like pyoderma; Deep mycoses; Donovanosis; Fungal infection; Granuloma inguinale; Granulomatous disease; Lymphogranuloma venereum.

Publication types

Review

MeSH terms

Acitretin / therapeutic use
Amphotericin B / therapeutic use
Anti-Bacterial Agents / therapeutic use*
Antifungal Agents / therapeutic use*
Azoles / therapeutic use
Blastomycosis / diagnosis
Blastomycosis / drug therapy
Coccidioidomycosis / diagnosis
Coccidioidomycosis / drug therapy
Cryptococcosis / diagnosis
Cryptococcosis / drug therapy
Dermatomycoses / diagnosis
Dermatomycoses / drug therapy*
Doxycycline / therapeutic use
Granuloma Inguinale / diagnosis
Granuloma Inguinale / drug therapy*
Histoplasmosis / diagnosis
Histoplasmosis / drug therapy
Humans
Keratolytic Agents / therapeutic use
Lymphogranuloma Venereum / diagnosis
Lymphogranuloma Venereum / drug therapy*
Mycoses / diagnosis
Mycoses / drug therapy*
Pyoderma / diagnosis
Pyoderma / drug therapy
Sexually Transmitted Diseases / diagnosis
Sexually Transmitted Diseases / drug therapy
Sporotrichosis / diagnosis
Sporotrichosis / drug therapy

Substances

Anti-Bacterial Agents
Antifungal Agents
Azoles
Keratolytic Agents
Amphotericin B
Acitretin
Doxycycline