Direct Reprogramming of RESTing Astrocytes

Chengzhong Wang; Helen Fong; Yadong Huang

doi:10.1016/j.stem.2015.06.011

Direct Reprogramming of RESTing Astrocytes

Cell Stem Cell. 2015 Jul 2;17(1):1-3. doi: 10.1016/j.stem.2015.06.011.

Authors

Chengzhong Wang¹, Helen Fong¹, Yadong Huang²

Affiliations

¹ Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
² Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: yadong.huang@gladstone.ucsf.edu.

PMID: 26140600
DOI: 10.1016/j.stem.2015.06.011

Abstract

Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity.

Publication types

Comment

MeSH terms

Animals
Astrocytes / cytology*
Astrocytes / metabolism*
Cellular Reprogramming / physiology*
Humans
Repressor Proteins / metabolism*

Substances

Repressor Proteins