Gold(I)-catalysed cascade reactions in the synthesis of 2,3-fused indole derivatives

Chem Commun (Camb). 2015 Aug 11;51(62):12384-7. doi: 10.1039/c5cc04606h.

Abstract

A gold(I)-catalysed hydroaminative/arylative cascade for the efficient synthesis of a variety of indole-fused skeletons has been developed. Factors controlling the catalyst loading required in these transformations involving 1,3-unsubstituted indole intermediates have been revealed, allowing isolation of an unprecedented 1,3-dimetallated 3H-indole gold complex characterized by X-ray diffraction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Gold / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • X-Ray Diffraction

Substances

  • Indoles
  • Gold