Complete genome sequence of Lactobacillus salivarius Ren, a probiotic strain with anti-tumor activity

Erna Sun; Fazheng Ren; Songling Liu; Shaoyang Ge; Ming Zhang; Huiyuan Guo; Lu Jiang; Hao Zhang; Liang Zhao

doi:10.1016/j.jbiotec.2015.06.399

Complete genome sequence of Lactobacillus salivarius Ren, a probiotic strain with anti-tumor activity

J Biotechnol. 2015 Sep 20:210:57-8. doi: 10.1016/j.jbiotec.2015.06.399. Epub 2015 Jun 29.

Authors

Erna Sun¹, Fazheng Ren², Songling Liu³, Shaoyang Ge⁴, Ming Zhang⁵, Huiyuan Guo⁶, Lu Jiang⁷, Hao Zhang⁸, Liang Zhao⁹

Affiliations

¹ The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China. Electronic address: erna_sun@163.com.
² The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: renfazheng@263.net.
³ Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China. Electronic address: 876910384@qq.com.
⁴ Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: 494676448@qq.com.
⁵ Beijing Higher Institution Engineering Research Center of Animal Product, Beijing 100083, China. Electronic address: 36103805@qq.com.
⁶ Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China. Electronic address: 5133323@qq.com.
⁷ Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: lujiang_edu@163.com.
⁸ The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: 80773680@qq.com.
⁹ The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: lzhao@cau.edu.cn.

PMID: 26133929
DOI: 10.1016/j.jbiotec.2015.06.399

Abstract

Lactobacillus salivarius Ren (LsR) (CGMCC No. 3606) is a probiotic strain that was isolated from the feces of a healthy centenarian living in Bama, Guangxi, China. Previous studies have shown that this strain decreases 4-nitroquinoline 1-oxide (4-NQO)-induced genotoxicity in vitro. It also suppresses 4-NQO-induced oral carcinogenesis and 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis, and therefore may be used as an adjuvant therapeutic agent for cancer. Here, we report the complete genome sequence of LsR that consists of a circular chromosome of 1751,565 bp and two plasmids (pR1, 176,951 bp; pR2, 49,848 bp).

Keywords: Cancer inhibition; Genome; Genotoxicity; Lactobacillus salivarius Ren; Single molecule real-time sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Antineoplastic Agents / pharmacology
Bacterial Proteins / genetics
Bacterial Proteins / pharmacology
Base Composition
China
Feces / microbiology
Genome Size
Genome, Bacterial*
Humans
Lactobacillus / genetics*
Molecular Sequence Data
Probiotics
Sequence Analysis, DNA / methods*

Substances

Antineoplastic Agents
Bacterial Proteins

Associated data

GENBANK/CP011403
GENBANK/CP011404
GENBANK/CP011405