Abstract
This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Chemistry, Organic / methods*
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Isoindoles / chemical synthesis*
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Isoindoles / chemistry
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Metals / chemistry*
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Molecular Conformation
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Pharmaceutical Preparations / chemistry
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
Substances
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Aza Compounds
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Isoindoles
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Metals
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Pharmaceutical Preparations
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Quinolines
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Spiro Compounds