Abstract
The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-λ1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-λ2/3 levels were found in children with recurrent wheezing at 36-month follow-up.
MeSH terms
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Bronchiolitis, Viral / epidemiology*
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Bronchiolitis, Viral / genetics
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Bronchiolitis, Viral / physiopathology
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Bronchiolitis, Viral / virology*
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Female
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Humans
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Infant
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Infant, Newborn
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Interferon-gamma / analysis
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Interferon-gamma / genetics
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Interferon-gamma / metabolism
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Male
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Respiratory Sounds / physiopathology*
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Respiratory Syncytial Virus Infections / epidemiology*
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Respiratory Syncytial Virus Infections / genetics
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Respiratory Syncytial Virus Infections / physiopathology
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Respiratory Syncytial Virus Infections / virology*
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Respiratory Syncytial Virus, Human
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Retrospective Studies
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Viral Load