Circulatory and Ventilatory Power: Characterization in Patients with Coronary Artery Disease

Arq Bras Cardiol. 2015 Jun;104(6):476-85. doi: 10.5935/abc.20150035. Epub 2015 May 5.
[Article in English, Portuguese]

Abstract

Background: Circulatory power (CP) and ventilatory power (VP) are indices that have been used for the clinical evaluation of patients with heart failure; however, no study has evaluated these indices in patients with coronary artery disease (CAD) without heart failure.

Objective: To characterize both indices in patients with CAD compared with healthy controls.

Methods: Eighty-seven men [CAD group = 42 subjects and healthy control group (CG) = 45 subjects] aged 40-65 years were included. Cardiopulmonary exercise testing was performed on a treadmill and the following parameters were measured: 1) peak oxygen consumption (VO2), 2) peak heart rate (HR), 3) peak blood pressure (BP), 4) peak rate-pressure product (peak systolic HR x peak BP), 5) peak oxygen pulse (peak VO2/peak HR), 6) oxygen uptake efficiency (OUES), 7) carbon dioxide production efficiency (minute ventilation/carbon dioxide production slope), 8) CP (peak VO2 x peak systolic BP) and 9) VP (peak systolic BP/carbon dioxide production efficiency).

Results: The CAD group had significantly lower values for peak VO2 (p < 0.001), peak HR (p < 0.001), peak systolic BP (p < 0.001), peak rate-pressure product (p < 0.001), peak oxygen pulse (p = 0.008), OUES (p < 0.001), CP (p < 0.001), and VP (p < 0.001) and significantly higher values for peak diastolic BP (p = 0.004) and carbon dioxide production efficiency (p < 0.001) compared with CG. Stepwise regression analysis showed that CP was influenced by group (R2 = 0.44, p < 0.001) and VP was influenced by both group and number of vessels with stenosis after treatment (interaction effects: R2 = 0.46, p < 0.001).

Conclusion: The indices CP and VP were lower in men with CAD than healthy controls.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Pressure / physiology*
  • Carbon Dioxide / metabolism
  • Case-Control Studies
  • Coronary Artery Disease / physiopathology*
  • Cross-Sectional Studies
  • Exercise / physiology
  • Exercise Test*
  • Exercise Tolerance / physiology*
  • Heart Rate / physiology
  • Humans
  • Male
  • Middle Aged
  • Oxygen Consumption / physiology*
  • Reference Values
  • Respiratory Function Tests
  • Statistics, Nonparametric
  • Time Factors

Substances

  • Carbon Dioxide

Grants and funding

This study was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), São Paulo/SP/Brasil (processo: 2010/52070-4); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brasília/DF/Brasil; Conselho Nacional de Desenvolvimento Científico e Tenológico (CNPq), Brasília/DF/Brasil (processo: 483945/2007-2).