New strategies for the prevention or treatment of infections are required. The purpose of this study is to evaluate the effects of antimicrobial peptides and bacteriocins isolated from Lactobacillus plantarum on growth and biofilm formation of three common pathogenic microbes. The antibacterial properties of the antimicrobial peptide Tet213 and bacteriocins were tested by the disc diffusion method. Tet213 and bacteriocins showed inhibitory effects on biofilm formation for the three organisms, as observed by fluorescence microscopy. Furthermore, Tet213 and the bacteriocins all showed antimicrobial activity against the three bacterial species, with Tet213 having a greater inhibitory effect on S. aureus than the bacteriocins (P < 0.05), while the bacteriocins showed stronger antimicrobial activity against S. sanguis (P < 0.05).
Keywords: Antimicrobial activity; antimicrobial peptide; bacteriocin; biofilm.