Abstract
Seven new nonadecaketides (1-7), lobophorols A-C, lobophopyranones A and B, and lobophorones A and B, along with the first naturally occurring related metabolites (8-10), were isolated from specimens of Lobophora variegata collected from the Canary Islands. Their structures were determined by extensive spectroscopic methods. In addition, an insight into the biosynthesis of these compounds on the basis of the involvement of type III polyketide synthases is proposed. Lobophorol A (1) showed significant antibacterial activity against Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification*
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Acetates / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Enterococcus faecalis / drug effects
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phaeophyceae / chemistry*
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Spain
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Staphylococcus aureus / drug effects
Substances
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Acetates
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Anti-Bacterial Agents
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Polyketides
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lobophorol A