Decreased SAPK/JNK signalling affects cytokine release and STAT3 activation in psoriatic fibroblasts

Exp Dermatol. 2015 Oct;24(10):800-2. doi: 10.1111/exd.12787. Epub 2015 Aug 21.

Authors

Jorge Arasa^{1

2}, María Carmen Terencio^{1

2}, Rosa M Andrés^{1

2}, Francisca Valcuende-Cavero^{3

4}, María Carmen Montesinos^{1

2}

Affiliations

¹ Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain.
² Center of Molecular Recognition and Technological Development (IDM), Valencia, Spain.
³ Department of Dermatology, University Hospital La Plana, Vila-real, Spain.
⁴ Department of Medicine and Surgery, CEU Cardenal Herrera University, Castellón de la Plana, Spain.

PMID: 26120912
DOI: 10.1111/exd.12787

No abstract available

Keywords: MAPkinases; STAT3; TNF-alpha; fibroblasts; psoriasis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Fibroblasts
Humans
Interleukin-6 / metabolism*
Interleukin-6 / pharmacology
Interleukin-8 / metabolism*
JNK Mitogen-Activated Protein Kinases / metabolism*
MAP Kinase Signaling System*
Mitogen-Activated Protein Kinase 1 / metabolism
Mitogen-Activated Protein Kinase 3 / metabolism
Phosphorylation
Psoriasis / metabolism*
Psoriasis / pathology
STAT3 Transcription Factor / metabolism*
Transcription Factor RelA / metabolism
Tumor Necrosis Factor-alpha / pharmacology
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Interleukin-6
Interleukin-8
STAT3 Transcription Factor
STAT3 protein, human
Transcription Factor RelA
Tumor Necrosis Factor-alpha
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
p38 Mitogen-Activated Protein Kinases