Neuropsychological tests for predicting cognitive decline in older adults

Neurodegener Dis Manag. 2015;5(3):191-201. doi: 10.2217/nmt.15.7.

Abstract

Aim: To determine neuropsychological tests likely to predict cognitive decline.

Methods: A sample of nonconverters (n = 106) was compared with those who declined in cognitive status (n = 24). Significant univariate logistic regression prediction models were used to create multivariate logistic regression models to predict decline based on initial neuropsychological testing.

Results: Rey-Osterrieth Complex Figure Test (RCFT) Retention predicted conversion to mild cognitive impairment (MCI) while baseline Buschke Delay predicted conversion to Alzheimer's disease (AD). Due to group sample size differences, additional analyses were conducted using a subsample of demographically matched nonconverters. Analyses indicated RCFT Retention predicted conversion to MCI and AD, and Buschke Delay predicted conversion to AD.

Conclusion: Results suggest RCFT Retention and Buschke Delay may be useful in predicting cognitive decline.

Keywords: Alzheimer's disease; cognitive decline; conversion; memory disorder; mild cognitive impairment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / psychology
  • Alzheimer Disease / diagnosis*
  • Cognitive Dysfunction / diagnosis*
  • Disease Progression
  • Humans
  • Logistic Models
  • Longitudinal Studies
  • Middle Aged
  • Multivariate Analysis
  • Neuropsychological Tests*
  • Prognosis