Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis

Lihong Tian; Jinhua Zhang; Shiji Xiao; Jinlong Huang; Yuanyuan Zhang; Jianzhen Shen

doi:10.1016/j.mgene.2015.05.003

Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis

Meta Gene. 2015 Jun 5:5:43-54. doi: 10.1016/j.mgene.2015.05.003. eCollection 2015 Sep.

Authors

Lihong Tian¹, Jinhua Zhang², Shiji Xiao¹, Jinlong Huang¹, Yuanyuan Zhang¹, Jianzhen Shen¹

Affiliations

¹ Fujian Insitute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.
² Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.

Abstract

The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of GGCX (rs699664 and rs12714145) and maintenance warfarin dose.

Keywords: CI, confidence interval; CYP2C9, cytochrome P450 complex subunit 2C9; CYP4F2, cytochrome P450 complex subunit 4F2; Chinese; EPHX1, epoxide hydro-lase 1 INR, International Normalized Ratio; GGCX; GGCX, gamma-glutamyl carboxylase; Gene polymorphisms; MDWD, mean daily warfarin dose; Meta-analysis; SD, standard deviation; SNPs, single nucleotide polymorphisms; Systematic review; VKORC1, vitamin K epoxide reductase complex subunit 1; WMD, weight mean difference; Warfarin.

Publication types

Review