Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia

Jennifer H Southcombe; Samantha J Benton; Yuxiang Hu; Peter von Dadelszen; Tim Child; James V Snider; Christopher W G Redman; Ian L Sargent; Ingrid Granne

doi:10.1016/j.preghy.2013.02.002

Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia

Pregnancy Hypertens. 2013 Apr;3(2):115-7. doi: 10.1016/j.preghy.2013.02.002. Epub 2013 Mar 6.

Authors

Jennifer H Southcombe¹, Samantha J Benton², Yuxiang Hu², Peter von Dadelszen², Tim Child³, James V Snider⁴, Christopher W G Redman⁵, Ian L Sargent⁵, Ingrid Granne³

Affiliations

¹ Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK. Electronic address: jen.southcombe@obs-gyn.ox.ac.uk.
² Departments of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
³ Oxford Fertility Unit and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
⁴ Critical Diagnostics, San Diego, CA, USA.
⁵ Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.

PMID: 26105947
DOI: 10.1016/j.preghy.2013.02.002

Abstract

A diagnostic test to confirm pre-eclampsia would be beneficial for the clinical management of the syndrome. The Triage PlGF test is able to confirm pre-eclampsia with high accuracy, with the greatest efficacy at <35weeks gestation. We recently found that the anti-inflammatory protein sST2 is elevated in the plasma of pre-eclamptic women compared to normal controls. Here sST2 and PlGF are compared in early-onset and late-onset pre-eclamptic women. sST2 was found to be an equally good diagnostic tool for early-onset (sST2 AUC 0.944 versus PlGF AUC 0.995; not significant) but not late-onset disease.

Keywords: Inflammation; Maternal immunity; PlGF; Pre-eclampsia; sST2.

Grants and funding

MR/J003360/1/MRC_/Medical Research Council/United Kingdom