PP050. NT-Pro-BNP: Correlation with adverse outcome markers in hypertensive gestational syndromes

Marcela Clelia Cabo Fustaret; Ana Escobar; Ricardo Illia; Matias Uranga Imaz; Carlos Rivas; Guillermo Lobenstein; Patricia Olejnik; Horacio Mayer; Martin De Anchorena; Mariana Strika; Barbara Climenti

doi:10.1016/j.preghy.2013.04.077

PP050. NT-Pro-BNP: Correlation with adverse outcome markers in hypertensive gestational syndromes

Pregnancy Hypertens. 2013 Apr;3(2):85. doi: 10.1016/j.preghy.2013.04.077. Epub 2013 Jun 6.

Authors

Marcela Clelia Cabo Fustaret, Ana Escobar, Ricardo Illia, Matias Uranga Imaz, Carlos Rivas, Guillermo Lobenstein, Patricia Olejnik, Horacio Mayer, Martin De Anchorena, Mariana Strika, Barbara Climenti

PMID: 26105906
DOI: 10.1016/j.preghy.2013.04.077

Abstract

Introduction: Brain-type natriuretic peptide is released by cardiomyocites in response to parietal stress augmentation and systemic endothelial dysfunction. Hypertensive Gestational Syndromes (HGS) share this mechanism, but the correlation between NT-Pro-BNP and maternal/fetal outcomes is not yet clear enough.

Objectives: Evaluate the correlation between NT-Pro-BNP in HGS and Normotensive Pregnant Women (NPW), with clinical and biological markers of adverse maternal/fetal outcome.

Methods: We performed a transversal case-control study to analyze NT-Pro-BNP and established markers in 87 patients with HGS and 95 NPW.

Results: The average gestational age at delivery (GAD) was: HGS 35.5 weeks, NPW 38.1 weeks; birth average weight (BAW): HGS 2616.2 gr, NPW 3281.6 gr; average maternal age (AMA): HGS 33.7 years, NPW 33.5 years; media NT-Pro-BNP (pg/ml): HGS 626.5, NPW 60.6. In the HGS media NT-Pro-BNP (pg/ml): HELLP 1342.3, Preeclampsia 686.7, Gestational hypertension 171.1, Chronic hypertension 108.5, the following significant correlations were found for NT-Pro-BNP relation to: Proteinuria p0.001, GOT p0.001, GPT p0.001, Platelets p0.001, Hematocrit p0.026,Uric acid p0.001, Alkaline phosphatase p0.001, LDH p0.001, GAD p0.004, BAW p0.010, AMA p0.042, cardiac failure p0.002, number of used anti-hypertensive drugs p0.004.

Conclusions: NT-Pro-BNP significantly correlates with markers of adverse maternal/fetal outcome in HGS and identify a high risk subgroup in these Syndromes.