Hepatitis: After HCV cure, HBV cure?

Nat Rev Gastroenterol Hepatol. 2015 Jul;12(7):376-8. doi: 10.1038/nrgastro.2015.103. Epub 2015 Jun 23.

Abstract

Current treatments efficiently control chronic HBV infection but they do not lead to its elimination. Now, Ebert and colleagues have shown that cellular inhibitor of apoptosis proteins (cIAPs) prevent TNF-mediated killing of infected hepatocytes and that cIAP antagonists might lead to HBV cure by promoting death of infected cells.

Publication types

  • News

MeSH terms

  • Animals
  • Disease Models, Animal
  • Hepatitis B / drug therapy*
  • Hepatitis B virus / drug effects*
  • Hepatocytes / drug effects*
  • Humans
  • Inhibitor of Apoptosis Proteins / antagonists & inhibitors*
  • Liver / pathology*
  • Mice
  • Receptors, Tumor Necrosis Factor, Type I / metabolism
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Inhibitor of Apoptosis Proteins
  • Receptors, Tumor Necrosis Factor, Type I
  • Tumor Necrosis Factor-alpha