Silica Nanopills for Targeted Anticancer Drug Delivery

Small. 2015 Sep;11(36):4626-31. doi: 10.1002/smll.201402930. Epub 2015 Jun 11.

Abstract

Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.

Keywords: antibodies; cancer therapy; drug delivery; microtubes; porous silicon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry*
  • Camptothecin / administration & dosage*
  • Cell Line, Tumor
  • Drug Delivery Systems*
  • Electrochemistry
  • Humans
  • Microscopy, Confocal
  • Microscopy, Electron, Scanning
  • Microtubules / chemistry
  • Nanomedicine / methods*
  • Nanoparticles / chemistry*
  • Neoplasms / metabolism
  • Nerve Tissue Proteins / chemistry
  • Neuroblastoma / drug therapy
  • Neuroblastoma / metabolism
  • Receptors, Nerve Growth Factor / chemistry
  • Silicon Dioxide / chemistry*
  • Surface Properties

Substances

  • Antineoplastic Agents
  • NGFR protein, human
  • Nerve Tissue Proteins
  • Receptors, Nerve Growth Factor
  • Silicon Dioxide
  • Camptothecin