Abstract
A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Chlorophyllides
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Drug Resistance, Neoplasm
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Humans
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Hydroxides / administration & dosage*
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Hydroxides / pharmacology
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Nanoparticles / administration & dosage*
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Photochemotherapy
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Photosensitizing Agents / administration & dosage*
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Photosensitizing Agents / pharmacology
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Platinum Compounds / administration & dosage*
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Platinum Compounds / pharmacology
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Porphyrins / administration & dosage*
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Porphyrins / pharmacology
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Prodrugs / administration & dosage*
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Prodrugs / pharmacology
Substances
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Antineoplastic Agents
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Chlorophyllides
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Hydroxides
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Photosensitizing Agents
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Platinum Compounds
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Porphyrins
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Prodrugs
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phytochlorin