Abstract
Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antimicrobial Cationic Peptides / chemistry*
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Antimicrobial Cationic Peptides / pharmacology*
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Chitosan / chemistry*
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Chitosan / pharmacology*
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / growth & development
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Erythrocytes / drug effects
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Hemolysis / drug effects
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Humans
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Microbial Sensitivity Tests
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Organosilicon Compounds / chemistry
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Wasp Venoms / chemistry*
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Wasp Venoms / pharmacology*
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Organosilicon Compounds
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Wasp Venoms
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anoplin
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t-butyldimethylsilyl compounds
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Chitosan