Abstract
Two new carbazole alkaloids, claulansine S (1) and claulansine T (2), and one new amide alkaloid, clauamide A (3), together with four known analogues (4-7) were isolated from the stems of Clausena lansium. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (HSQC, HMBC, and NOE experiments). Compounds 4 and 6 showed moderate hepatoprotective activities.
Keywords:
Clausena lansium; Rutaceae; alkaloids; hepatoprotective.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Amides / chemistry
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Amides / isolation & purification*
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Amides / pharmacology
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Clausena / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Liver / drug effects
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Liver / metabolism
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Liver / pathology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
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Protective Agents / pharmacology
Substances
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Alkaloids
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Amides
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Carbazoles
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Drugs, Chinese Herbal
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Protective Agents
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claulansine S
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claulansine T